图数据管理和查询具有许多实际应用。当图形非常异构和/或用户不熟悉其结构时，即使用户无法描述连接，他们也可能需要找到如何在图中连接两个或多个节点的组。这仅由现有查询语言部分支持，这些语言允许搜索路径，但不适合连接三个或更多节点组的树。后者与NP-HARD组Steiner树问题有关，以前已考虑用于数据库中的关键字搜索。在这项工作中，我们正式展示了如何在诸如SPARQL或Cypher之类的图形语言中集成连接的树模式（CTPS，简称CTP），从而导致扩展查询语言（或简而言之）。然后，我们研究一组评估CTP的算法；我们概括了先前的关键字搜索工作，最重要的是（i）考虑双向边缘遍历遍历和（ii）允许用户选择任何分数功能来排名CTP结果。为了应对非常大的搜索空间，我们提出了一种有效的修剪技术，并正式建立了大量的情况，即使我们的算法molesp也可以完成修剪。我们的实验验证了我们在大量合成和现实世界中的CTP和EQL评估算法的性能。

深度学习（DL）模型为各种医学成像基准挑战提供了最先进的性能，包括脑肿瘤细分（BRATS）挑战。然而，局灶性病理多隔室分割（例如，肿瘤和病变子区）的任务特别具有挑战性，并且潜在的错误阻碍DL模型转化为临床工作流程。量化不确定形式的DL模型预测的可靠性，可以实现最不确定的地区的临床审查，从而建立信任并铺平临床翻译。最近，已经引入了许多不确定性估计方法，用于DL医学图像分割任务。开发指标评估和比较不确定性措施的表现将有助于最终用户制定更明智的决策。在本研究中，我们探索并评估在Brats 2019-2020任务期间开发的公制，以对不确定量化量化（Qu-Brats），并旨在评估和排列脑肿瘤多隔室分割的不确定性估计。该公制（1）奖励不确定性估计，对正确断言产生高置信度，以及在不正确的断言处分配低置信水平的估计数，（2）惩罚导致更高百分比的无关正确断言百分比的不确定性措施。我们进一步基准测试由14个独立参与的Qu-Brats 2020的分割不确定性，所有这些都参与了主要的Brats细分任务。总体而言，我们的研究结果证实了不确定性估计提供了分割算法的重要性和互补价值，因此突出了医学图像分析中不确定性量化的需求。我们的评估代码在HTTPS://github.com/ragmeh11/qu-brats公开提供。

哥内克人Sentinel Imagery的纯粹卷的可用性为使用深度学习的大尺度创造了新的土地利用陆地覆盖（Lulc）映射的机会。虽然在这种大型数据集上培训是一个非琐碎的任务。在这项工作中，我们试验Lulc Image分类和基准不同最先进模型的Bigearthnet数据集，包括卷积神经网络，多层感知，视觉变压器，高效导通和宽残余网络（WRN）架构。我们的目标是利用分类准确性，培训时间和推理率。我们提出了一种基于用于网络深度，宽度和输入数据分辨率的WRNS复合缩放的高效导通的框架，以有效地训练和测试不同的模型设置。我们设计一种新颖的缩放WRN架构，增强了有效的通道注意力机制。我们提出的轻量级模型具有较小的培训参数，实现所有19个LULC类的平均F分类准确度达到4.5％，并且验证了我们使用的resnet50最先进的模型速度快两倍作为基线。我们提供超过50种培训的型号，以及我们在多个GPU节点上分布式培训的代码。

Given a large graph with few node labels, how can we (a) identify the mixed network-effect of the graph and (b) predict the unknown labels accurately and efficiently? This work proposes Network Effect Analysis (NEA) and UltraProp, which are based on two insights: (a) the network-effect (NE) insight: a graph can exhibit not only one of homophily and heterophily, but also both or none in a label-wise manner, and (b) the neighbor-differentiation (ND) insight: neighbors have different degrees of influence on the target node based on the strength of connections. NEA provides a statistical test to check whether a graph exhibits network-effect or not, and surprisingly discovers the absence of NE in many real-world graphs known to have heterophily. UltraProp solves the node classification problem with notable advantages: (a) Accurate, thanks to the network-effect (NE) and neighbor-differentiation (ND) insights; (b) Explainable, precisely estimating the compatibility matrix; (c) Scalable, being linear with the input size and handling graphs with millions of nodes; and (d) Principled, with closed-form formula and theoretical guarantee. Applied on eight real-world graph datasets, UltraProp outperforms top competitors in terms of accuracy and run time, requiring only stock CPU servers. On a large real-world graph with 1.6M nodes and 22.3M edges, UltraProp achieves more than 9 times speedup (12 minutes vs. 2 hours) compared to most competitors.

Tongue cancer is a common oral cavity malignancy that originates in the mouth and throat. Much effort has been invested in improving its diagnosis, treatment, and management. Surgical removal, chemotherapy, and radiation therapy remain the major treatment for tongue cancer. The survival of patients determines the treatment effect. Previous studies have identified certain survival and risk factors based on descriptive statistics, ignoring the complex, nonlinear relationship among clinical and demographic variables. In this study, we utilize five cutting-edge machine learning models and clinical data to predict the survival of tongue cancer patients after treatment. Five-fold cross-validation, bootstrap analysis, and permutation feature importance are applied to estimate and interpret model performance. The prognostic factors identified by our method are consistent with previous clinical studies. Our method is accurate, interpretable, and thus useable as additional evidence in tongue cancer treatment and management.

High content imaging assays can capture rich phenotypic response data for large sets of compound treatments, aiding in the characterization and discovery of novel drugs. However, extracting representative features from high content images that can capture subtle nuances in phenotypes remains challenging. The lack of high-quality labels makes it difficult to achieve satisfactory results with supervised deep learning. Self-Supervised learning methods, which learn from automatically generated labels has shown great success on natural images, offer an attractive alternative also to microscopy images. However, we find that self-supervised learning techniques underperform on high content imaging assays. One challenge is the undesirable domain shifts present in the data known as batch effects, which may be caused by biological noise or uncontrolled experimental conditions. To this end, we introduce Cross-Domain Consistency Learning (CDCL), a novel approach that is able to learn in the presence of batch effects. CDCL enforces the learning of biological similarities while disregarding undesirable batch-specific signals, which leads to more useful and versatile representations. These features are organised according to their morphological changes and are more useful for downstream tasks - such as distinguishing treatments and mode of action.

While risk-neutral reinforcement learning has shown experimental success in a number of applications, it is well-known to be non-robust with respect to noise and perturbations in the parameters of the system. For this reason, risk-sensitive reinforcement learning algorithms have been studied to introduce robustness and sample efficiency, and lead to better real-life performance. In this work, we introduce new model-free risk-sensitive reinforcement learning algorithms as variations of widely-used Policy Gradient algorithms with similar implementation properties. In particular, we study the effect of exponential criteria on the risk-sensitivity of the policy of a reinforcement learning agent, and develop variants of the Monte Carlo Policy Gradient algorithm and the online (temporal-difference) Actor-Critic algorithm. Analytical results showcase that the use of exponential criteria generalize commonly used ad-hoc regularization approaches. The implementation, performance, and robustness properties of the proposed methods are evaluated in simulated experiments.

Hierarchical learning algorithms that gradually approximate a solution to a data-driven optimization problem are essential to decision-making systems, especially under limitations on time and computational resources. In this study, we introduce a general-purpose hierarchical learning architecture that is based on the progressive partitioning of a possibly multi-resolution data space. The optimal partition is gradually approximated by solving a sequence of optimization sub-problems that yield a sequence of partitions with increasing number of subsets. We show that the solution of each optimization problem can be estimated online using gradient-free stochastic approximation updates. As a consequence, a function approximation problem can be defined within each subset of the partition and solved using the theory of two-timescale stochastic approximation algorithms. This simulates an annealing process and defines a robust and interpretable heuristic method to gradually increase the complexity of the learning architecture in a task-agnostic manner, giving emphasis to regions of the data space that are considered more important according to a predefined criterion. Finally, by imposing a tree structure in the progression of the partitions, we provide a means to incorporate potential multi-resolution structure of the data space into this approach, significantly reducing its complexity, while introducing hierarchical feature extraction properties similar to certain classes of deep learning architectures. Asymptotic convergence analysis and experimental results are provided for clustering, classification, and regression problems.

Being able to forecast the popularity of new garment designs is very important in an industry as fast paced as fashion, both in terms of profitability and reducing the problem of unsold inventory. Here, we attempt to address this task in order to provide informative forecasts to fashion designers within a virtual reality designer application that will allow them to fine tune their creations based on current consumer preferences within an interactive and immersive environment. To achieve this we have to deal with the following central challenges: (1) the proposed method should not hinder the creative process and thus it has to rely only on the garment's visual characteristics, (2) the new garment lacks historical data from which to extrapolate their future popularity and (3) fashion trends in general are highly dynamical. To this end, we develop a computer vision pipeline fine tuned on fashion imagery in order to extract relevant visual features along with the category and attributes of the garment. We propose a hierarchical label sharing (HLS) pipeline for automatically capturing hierarchical relations among fashion categories and attributes. Moreover, we propose MuQAR, a Multimodal Quasi-AutoRegressive neural network that forecasts the popularity of new garments by combining their visual features and categorical features while an autoregressive neural network is modelling the popularity time series of the garment's category and attributes. Both the proposed HLS and MuQAR prove capable of surpassing the current state-of-the-art in key benchmark datasets, DeepFashion for image classification and VISUELLE for new garment sales forecasting.

Stacking (or stacked generalization) is an ensemble learning method with one main distinctiveness from the rest: even though several base models are trained on the original data set, their predictions are further used as input data for one or more metamodels arranged in at least one extra layer. Composing a stack of models can produce high-performance outcomes, but it usually involves a trial-and-error process. Therefore, our previously developed visual analytics system, StackGenVis, was mainly designed to assist users in choosing a set of top-performing and diverse models by measuring their predictive performance. However, it only employs a single logistic regression metamodel. In this paper, we investigate the impact of alternative metamodels on the performance of stacking ensembles using a novel visualization tool, called MetaStackVis. Our interactive tool helps users to visually explore different singular and pairs of metamodels according to their predictive probabilities and multiple validation metrics, as well as their ability to predict specific problematic data instances. MetaStackVis was evaluated with a usage scenario based on a medical data set and via expert interviews.